Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1)-Reference-Cited by-同舟云学术

Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1)

Published:2011-11 Issue:22 Volume:21 Page:6693-6698
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Wu Shung C.,Yoon David,Chin Janice,van Kirk Katy,Seethala Ramakrishna,Golla Rajasree,He Bin,Harrity Thomas,Kunselman Lori K.,Morgan Nathan N.,Ponticiello Randolph P.,Taylor Joseph R.,Zebo Rachel,Harper Timothy W.,Li Wenying,Wang Mengmeng,Zhang Lisa,Sleczka Bogdan G.,Nayeem Akbar,Sheriff Steven,Camac Daniel M.,Morin Paul E.,Everlof John G.,Li Yi-Xin,Ferraro Cheryl A.,Kieltyka Kasia,Shou Wilson,Vath Marianne B.,Zvyaga Tatyana A.,Gordon David A.,Robl Jeffrey A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. Global Prevalence of Diabetes

2. The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes

3. Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

4. The Role of 11Beta-Hydroxysteroid Dehydrogenase in Metabolic Disease and Therapeutic Potential of 11Beta-HSD1 Inhibitors

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