Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate-Reference-Cited by-同舟云学术

Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate

Published:2010-09 Issue:17 Volume:20 Page:5313-5319
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Anselm Lilli,Banner David W.,Benz Jörg,Groebke Zbinden Katrin,Himber Jacques,Hilpert Hans,Huber Walter,Kuhn Bernd,Mary Jean-Luc,Otteneder Michael B.,Panday Narendra,Ricklin Fabienne,Stahl Martin,Thomi Stefan,Haap Wolfgang

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference42 articles.

1. CDC/NCHS/AHA, 2003 data.

2. Comparative Pharmacodynamics and Pharmacokinetics of Oral Direct Thrombin and Factor Xa Inhibitors in Development

3. Oral anticoagulation with factor Xa and thrombin inhibitors: on the threshold of change

4. Direct inhibitors of coagulation proteins – the end of the heparin and low-molecular-weight heparin era for anticoagulant therapy?

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