Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP-Reference-Cited by-同舟云学术

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP

Published:2006-06 Issue:12 Volume:16 Page:3175-3179
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Cox Christopher D.,Torrent Maricel,Breslin Michael J.,Mariano Brenda J.,Whitman David B.,Coleman Paul J.,Buser Carolyn A.,Walsh Eileen S.,Hamilton Kelly,Schaber Michael D.,Lobell Robert B.,Tao Weikang,South Vicki J.,Kohl Nancy E.,Yan Youwei,Kuo Lawrence C.,Prueksaritanont Thomayant,Slaughter Donald E.,Li Chunze,Mahan Elizabeth,Lu Bing,Hartman George D.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP

2. Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

3. Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

4. Past and future of the mitotic spindle as an oncology target

5. Motor Function in the Mitotic Spindle Minireview

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