Design and synthesis of novel spirocyclic carboxylic acids as potent and orally bioavailable DGAT1 inhibitors and their biological evaluation-Reference-Cited by-同舟云学术

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Design and synthesis of novel spirocyclic carboxylic acids as potent and orally bioavailable DGAT1 inhibitors and their biological evaluation

Published:2022-04 Issue: Volume:62 Page:128632
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Koul Summon,Kurhade Suresh,Bhosale Sandeep,Naik Keshav,Salunkhe Videsh,Ravula Sudhir,Punde Prasad,Velayutham Ravikumar,Tiwari Atul,Ahl Daniela,Malkapuram Srividya,Mudagala Vamsi,Raje Amol,Umrani Dhananjay,Tambe Suhas,Patil Poonam,Singh Umesh,Bhuniya Debnath,Hariharan Narayanan,Mookhtiar Kasim

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference37 articles.

1. Dysregulation of fatty acid metabolism in the etiology of Type 2 diabetes;McGarry;Diabetes,2002

2. (a) Chen HC, Farese RV Jr. DGAT and triglyceride synthesis: A new target for obesity treatment? Trends Cardiovasc. Med. 2000

3. 10:188-192. https://doi.org/10.1016/S1050-1738(00)00066-9 (b) Farese RV Jr, Cases S, Smith SJ. Triglyceride synthesis: insights from the cloning of diacylglycerolacyltransferase. Curr. Opin. Lipidol. 2000

4. (a) Chen HC, Farese RV Jr. DGAT and triglyceride synthesis: A new target for obesity treatment? Trends Cardiovasc. Med. 2000; 10:188-192. https://doi.org/10.1016/S1050-1738(00)00066-9

5. (b) Farese RV Jr, Cases S, Smith SJ. Triglyceride synthesis: insights from the cloning of diacylglycerolacyltransferase. Curr. Opin. Lipidol. 2000; 11:229-234. doi: 10.1097/00041433-200006000-00002.

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