Design, synthesis of auristatins-glucuronide conjugates targeting the β-glucuronidase in tumor microenvironment

Author:

Wang Yujie,Xu Keshi,Liu HongchunORCID,Zhang WeiORCID,Hu ChunORCID,Li YingxiaORCID

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

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4. Kim; Margolin; Jeffrey; Longmate; Timothy; W.; Synold; David; R.; Drugs, G. J. I. N., Dolastatin-10 in Metastatic Melanoma: A Phase II and Pharmokinetic Trial of the California Cancer Consortium. 2001.

5. Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate;Okeley;Clin Cancer Res,2010

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