Discovery of potent, soluble and orally active TRPV1 antagonists. Structure–activity relationships of a series of isoxazoles-Reference-Cited by-同舟云学术

Discovery of potent, soluble and orally active TRPV1 antagonists. Structure–activity relationships of a series of isoxazoles

Published:2011-08 Issue:15 Volume:21 Page:4652-4657
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ratcliffe Paul,Abernethy Lynn,Ansari Nasrin,Cameron Ken,Clarkson Tom,Dempster Maureen,Dunn David,Easson Anna-Marie,Edwards Darren,Everett Katy,Feilden Helen,Ho Koc-Kan,Kultgen Steve,Littlewood Peter,Maclean John,McArthur Duncan,McGregor Deborah,McLuskey Hazel,Neagu Irina,Nimz Olaf,Nisbet Lesley-Anne,Ohlmeyer Michael,Palin Ronnie,Pham Quynhchi,Rong Yajing,Roughton Andrew,Sammons Melanie,Swanson Robert,Tracey Heather,Walker Glenn

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference29 articles.

1. The diversity in the vanilloid (TRPV) receptor family of ion channels

2. A Unified Nomenclature for the Superfamily of TRP Cation Channels

3. The trp ion channel family

4. Transient Receptor Potential Cation Channels in Disease

5. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

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