Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands-Reference-Cited by-同舟云学术

Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands

Published:2017-06 Issue:11 Volume:27 Page:2432-2438
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ghosh Arun K.,Brindisi Margherita,Yen Yu-Chen,Cárdenas Emilio L.,Ella-Menye Jean-Rene,Kumaragurubaran Nagaswamy,Huang Xiangping,Tang Jordan,Mesecar Andrew D.

Funder

National Institutes of Health

Purdue University Office of the Executive Vice President for Research

Purdue Center for Cancer Research

NIH

U.S. Department of Energy (DOE) Office of Science

DOE Office of Science by Argonne National Laboratory

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference36 articles.

1. Alzheimer's Association 2016 Alzheimer's Disease Facts and Figures Available at: www.alz.org/alzheimers_disease_facts_figures.asp.

2. Current concepts in Alzheimer’s Disease: molecules, models and translational perspectives

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4. The global prevalence of dementia: A systematic review and metaanalysis

5. BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

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