Discovery of a novel series of cyclic urea as potent CCR5 antagonists-Reference-Cited by-同舟云学术

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Discovery of a novel series of cyclic urea as potent CCR5 antagonists

Published:2011-11 Issue:21 Volume:21 Page:6381-6385
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Duan Maosheng,Kazmierski Wieslaw M.,Tallant Matt,Jun Jung Ho,Edelstein Mark,Ferris Rob,Todd Dan,Wheelan Pat,Xiong Zhiping

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference7 articles.

1. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

2. Chapter 19 Small Molecule CCR5 and CXCR4-Based Viral Entry Inhibitors for Anti-HIV Therapy Currently in Development

3. Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc

4. Kazmierski, W. M.; Chong, P. Y.; Duan, M. PCT Int. Appl., WO 2009058919, 2009.

5. The Relative Activity of “Function Sparing” HIV-1 Entry Inhibitors on Viral Entry and CCR5 Internalization: Is Allosteric Functional Selectivity a Valuable Therapeutic Property?

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