Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties-Reference-Cited by-同舟云学术

Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties

Published:2014-03 Issue:6 Volume:24 Page:1615-1620
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Xiao Dong,Zhu Xiaohong,Yu Younong,Shao Ning,Wu Jie,McCormick Kevin D.,Dhondi Pawan,Qin Jun,Mazzola Robert,Tang Haiqun,Rao Ashwin,Siliphaivanh Phieng,Qiu Hongchen,Yang Xiaoxin,Rivelli Maria,Garlisi Charles G.,Eckel Steve,Mukhopadhyay Gitali,Correll Craig,Rindgen Diane,Aslanian Robert,Palani Anandan

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference42 articles.

1. Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis

2. Recent Advances in the Discovery and Development of CRTh2 Antagonists

3. Prostaglandin D2 Receptor CRTH2 Antagonists for the Treatment of Inflammatory Diseases

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