Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors-Reference-Cited by-同舟云学术

Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors

Published:2013-06 Issue:11 Volume:23 Page:3438-3442
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Plummer Mark S.,Cornicelli Joseph,Roark Howard,Skalitzky Donald J.,Stankovic Charles J.,Bove Susan,Pandit Jayvardhan,Goodman Annise,Hicks James,Shahripour Aurash,Beidler David,Lu Xiao Kang,Sanchez Brian,Whitehead Christopher,Sarver Ron,Braden Timothy,Gowan Richard,Shen Xi Qiang,Welch Katherine,Ogden Adam,Sadagopan Nalini,Baum Heidi,Miller Howard,Banotai Craig,Spessard Cindy,Lightle Sandra

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. Advances in the development of novel analgesics

2. A new chemical tool for exploring the physiological function of the PDE2 isozyme

3. An update on phosphodiesterase (PDE) inhibitors: Phosphodiesterases and drug selectivity

4. ANP-mediated cGMP signaling and phosphodiesterase inhibition in the rat cervical spinal cord

5. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats

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