Novel C-7 carbon substituted fourth generation fluoroquinolones targeting N. Gonorrhoeae infections

Author:

Kirk RalphORCID,Betson Mark,Bingham Matilda,Doyle Paul,Harvey Rebecca,Huxley Anthony,Moat John,Pesnot Thomas,Tait Michael,Hallworth Sebastian,Nelson Gary

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference30 articles.

1. Drug Trials Snapshots: BAXDELA | FDA. https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-baxdela.

2. FDA Approves New Indication for Delafloxacin for CABP. Medscape. Accessed December 10, 2019. http://www.medscape.com/viewarticle/920429.

3. In vitro activity of delafloxacin tested against isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis;Flamm;Antimicrob Agents Chemother.,2016

4. Contrasting effects of acidic pH on the extracellular and intracellular activities of the anti-gram-positive fluoroquinolones moxifloxacin and delafloxacin against Staphylococcus aureus;Lemaire;Antimicrob Agents Chemother.,2011

5. Efficacy and Safety of Single-Dose Oral Delafloxacin Compared With Intramuscular Ceftriaxone for Uncomplicated Gonorrhea Treatment;Hook;Sex Transm Dis.,2019

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