Design, synthesis and evaluation of 2-amino-imidazol-4-one derivatives as potent β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) inhibitors-Reference-Cited by-同舟云学术

Design, synthesis and evaluation of 2-amino-imidazol-4-one derivatives as potent β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) inhibitors

Published:2019-12 Issue:24 Volume:29 Page:126772
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Fan Tian-Yuan,Wu Wen-Yu,Yu Shao-Peng,Zhong Yue,Zhao Chao,Chen Min,Li He-Min,Li Nian-Guang,Chen Zhi,Chen Sai,Sun Zhi-Hui,Duan Jin-Ao,Shi Zhi-Hao

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Jiangsu Province

Priority Academic Program Development of Jiangsu Higher Education Institutions

Flagship Major Development of Jiangsu Higher Education Institutions

State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer’s disease

2. Alzheimer's disease

3. Alzheimer's Disease: The Amyloid Cascade Hypothesis

4. Copper, iron and zinc in Alzheimer's disease senile plaques

5. The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease

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