Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule-Reference-Cited by-同舟云学术

Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule

Published:2013-03 Issue:6 Volume:23 Page:1860-1864
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Poslusney Michael S.,Melancon Bruce J.,Gentry Patrick R.,Sheffler Douglas J.,Bridges Thomas M.,Utley Thomas J.,Daniels J. Scott,Niswender Colleen M.,Conn P. Jeffrey,Lindsley Craig W.,Wood Michael R.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse, and Parkinson’s Disease

2. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

3. Xanomeline: A selective muscarinic agonist for the treatment of Alzheimer's disease

4. Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia

5. Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor

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