Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure–activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1-Reference-Cited by-同舟云学术

Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure–activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1

Published:2014-02 Issue:4 Volume:24 Page:1201-1208
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Sifferlen Thierry,Boller Amandine,Chardonneau Audrey,Cottreel Emmanuelle,Hoecker Johannes,Aissaoui Hamed,Williams Jodi T.,Brotschi Christine,Heidmann Bibia,Siegrist Romain,Gatfield John,Treiber Alexander,Brisbare-Roch Catherine,Jenck Francois,Boss Christoph

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference34 articles.

1. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

2. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

3. Orexin Receptor Antagonists: A New Concept In CNS Disorders?

4. Orexin receptor antagonists: a review of promising compounds patented since 2006

5. Discovery of Dual Orexin Receptor Antagonists (DORAs) for the Treatment of Insomnia

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of 1,5-Substituted Pyrrolidin-2-ones from Donor–Acceptor Cyclopropanes and Anilines/Benzylamines;Molecules;2022-12-02

2. 4‐(Dimethylamino)Pyridinium Azide in Protic Ionic Liquid Media as a Stable Equivalent of Hydrazoic Acid;Advanced Synthesis & Catalysis;2022-06-30

3. Counterbalanced microcircuits for Orx1 and Orx2 regulation of stress reactivity;Medicine in Drug Discovery;2020-12

4. Synthesis of Benzyl Amines via Copper-Catalyzed Enantioselective Aza-Friedel–Crafts Addition of Phenols to N-Sulfonyl Aldimines;Organic Letters;2018-03-28

5. Convenient approach to polyoxygenated dibenzo[c,e]pyrrolo[1,2-a]azepines from donor–acceptor cyclopropanes;Organic Chemistry Frontiers;2018