Discovery of pyrrolidine-based β-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency-Reference-Cited by-同舟云学术

Discovery of pyrrolidine-based β-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency

Published:2012-01 Issue:1 Volume:22 Page:240-244
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Stachel Shawn J.,Steele Thomas G.,Petrocchi Alessia,Haugabook Sharie J.,McGaughey Georgia,Katharine Holloway M.,Allison Timothy,Munshi Sanjeev,Zuck Paul,Colussi Dennis,Tugasheva Katherine,Wolfe Abigail,Graham Samuel L.,Vacca Joseph P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference12 articles.

1. Progress toward the development of a viable BACE-1 inhibitor

2. Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase‡

3. 2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme): Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

4. Acylguanidines as Small-Molecule β-Secretase Inhibitors

5. Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1

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