Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition-Reference-Cited by-同舟云学术

Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition

Published:2021-07 Issue: Volume:43 Page:128048
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Akiu Mayuko,Tsuji Takashi,Sogawa Yoshitaka^ORCID,Terayama Koji,Yokoyama Mika,Tanaka Jun^ORCID,Asano Daigo,Sakurai Ken,Sergienko Eduard,Sessions E. Hampton,Gardell Stephen J.^ORCID,Pinkerton Anthony B.,Nakamura Tsuyoshi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference37 articles.

1. NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

2. NAD+ and sirtuins in aging and disease

3. NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

4. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death;Journal of Medicinal Chemistry;2024-04-05

2. Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives;Bioorganic & Medicinal Chemistry;2024-02

3. Synthesis, Optimization, and Structure–Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs);Journal of Medicinal Chemistry;2023-12-14

4. Triazolopyridine, a leitmotif of synthetic methods and pharmacological attributes: An extensive review;Arabian Journal of Chemistry;2023-10

5. Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns;Endocrine Reviews;2023-06-26