The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase-Reference-Cited by-同舟云学术

The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

Published:2009-10 Issue:20 Volume:19 Page:5950-5953
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Malagu Karine,Duggan Heather,Menear Keith,Hummersone Marc,Gomez Sylvie,Bailey Christine,Edwards Peter,Drzewiecki Jan,Leroux Frédéric,Quesada Mar Jimenez,Hermann Gesine,Maine Stephanie,Molyneaux Carrie-Anne,Le Gall Armelle,Pullen James,Hickson Ian,Smith Lisa,Maguire Sharon,Martin Niall,Smith Graeme,Pass Martin

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Targeting mTOR signaling for cancer therapy

2. Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

3. A mammalian protein targeted by G1-arresting rapamycin–receptor complex

4. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

5. Phosphatidylinositol 3-kinase related kinases

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