Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56Lck-Reference-Cited by-同舟云学术

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56Lck

Published:2003-11 Issue:22 Volume:13 Page:4007-4010
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Wityak John,Das Jagabandhu,Moquin Robert V.,Shen Zhongqi,Lin James,Chen Ping,Doweyko Arthur M.,Pitt Sidney,Pang Suhong,Shen Ding Ren,Fang Qiong,de Fex Henry F.,Schieven Gary L.,Kanner Steven B.,Barrish Joel C.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Profound block in thymocyte development in mice lacking p56lck

2. A dominant-negative transgene defines a role for p56lck in thymopoiesis.

3. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

4. The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

5. Signal transduction by lymphocyte antigen receptors

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