Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: Scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation-Reference-Cited by-同舟云学术

Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: Scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation

Published:2014-11 Issue:22 Volume:24 Page:5175-5180
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Sakamoto Toshiaki,Koga Yuichi,Hikota Masataka,Matsuki Kenji,Murakami Michino,Kikkawa Kohei,Fujishige Kotomi,Kotera Jun,Omori Kenji,Morimoto Hiroshi,Yamada Koichiro

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. Viagra® (sildenafil citrate). Summary of product specifications. New York, Pfizer Ltd, 2003.

2. Levitra®, vardenafil hydrochloride. Summary of product specifications. Bayer Healthcare, 2003.

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