Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors-Reference-Cited by-同舟云学术

Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors

Published:2015-09 Issue:17 Volume:25 Page:3436-3441
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Liu Gang,Abraham Sunny,Liu Xing,Xu Shimin,Rooks Allison M.,Nepomuceno Ron,Dao Alan,Brigham Daniel,Gitnick Dana,Insko Darren E.,Gardner Michael F.,Zarrinkar Patrick P.,Christopher Ron,Belli Barbara,Armstrong Robert C.,Holladay Mark W.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. The roles of FLT3 in hematopoiesis and leukemia

2. Prognostic significance of FLT3 ITD and D835 mutations in AML patients

3. FLT3 as a therapeutic target in AML: still challenging after all these years

4. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

5. Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

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