Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition-Reference-Cited by-同舟云学术

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Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition

Published:2017-11 Issue:21 Volume:27 Page:4838-4843
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Lawhorn Brian G.,Tran Tritin,Hong Victor S.,Morgan Lisa A.,Le BaoChau T.,Harpel Mark R.,Jolivette Larry,Diaz Elsie,Schwartz Benjamin,Gross Jeffrey W.,Tomaszek Thaddeus,Semus Simon,Concha Nestor,Smallwood Angela,Holt Dennis A.,Kallander Lara S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Aliskiren: a renin inhibitor offering a new approach for the treatment of hypertension

2. Oral renin inhibitors

3. Aliskiren: the first renin inhibitor for clinical treatment

4. Recent progress on the discovery of non-peptidic direct renin inhibitors for the clinical management of hypertension

5. Direct Renin Inhibitors as a New Therapy for Hypertension

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