Can generative AI replace immunofluorescent staining processes? A comparison study of synthetically generated cellpainting images from brightfield

Author:

Xing Xiaodan,Murdoch Siofra,Tang ChunlingORCID,Papanastasiou Giorgos,Cross-Zamirski JanORCID,Guo YunzheORCID,Xiao Xianglu,Schönlieb Carola-Bibiane,Wang YinhaiORCID,Yang GuangORCID

Funder

NVIDIA Corp

UKRI

Boehringer Ingelheim Corp USA

Royal Society

H2020

MRC

IMI

NIHR Imperial Biomedical Research Centre

Publisher

Elsevier BV

Reference28 articles.

1. In silico labeling: predicting fluorescent labels in unlabeled images;Christiansen;Cell,2018

2. DeepHCS: bright-field to fluorescence microscopy image conversion using deep learning for label-free high-content screening;Lee,2018

3. DeepHCS++: Bright-field to fluorescence microscopy image conversion using multi-task learning with adversarial losses for label-free high-content screening;Lee;Med. Image Anal.,2021

4. Extracting quantitative biological information from bright-field cell images using deep learning;Helgadottir;Biophys. Rev.,2021

5. Label-free prediction of cell painting from brightfield images;Cross-Zamirski;Sci. Rep.,2022

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