Structure-guided discovery of novel potent and efficacious proteolysis targeting chimera (PROTAC) degrader of BRD4-Reference-Cited by-同舟云学术

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Structure-guided discovery of novel potent and efficacious proteolysis targeting chimera (PROTAC) degrader of BRD4

Published:2021-10 Issue: Volume:115 Page:105238
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Xiang Wang,Wang Qiwei,Ran Kai,Ren Jing,Shi Yaojie,Yu Luoting

Funder

Ministry of Science and Technology of the People's Republic of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference42 articles.

1. Histone recognition and large-scale structural analysis of the human bromodomain family;Filippakopoulos;Cell,2012

2. Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer;Faivre;Nature,2020

3. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation;Gilan;Science (New York, NY).,2020

4. Targeting chromatin defects in selected solid tumors based on oncogene addiction, synthetic lethality and epigenetic antagonism;Morel;Ann. Oncol.,2017

5. BET bromodomains as novel epigenetic targets for brain health and disease;Singh;Neuropharmacology.,2020

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Proteolysis Targeting Chimeras (PROTACs) based on celastrol induce multiple protein degradation for triple-negative breast cancer treatment;European Journal of Pharmaceutical Sciences;2024-01

2. Discovery of intracellular self-assembly protein degraders driven by tumor-specific activatable bioorthogonal reaction;European Journal of Medicinal Chemistry;2023-09

3. Development of PROTAC degrader probe of CDK4/6 based on DCAF16;Bioorganic Chemistry;2023-09

4. Identification of highly efficacious PROTACs targeting BRD4 against acute myeloid leukemia: Design, synthesis, and biological evaluations;Chinese Chemical Letters;2023-06

5. Ugi reaction-assisted assembly of covalent PROTACs against glutathione peroxidase 4;Bioorganic Chemistry;2023-05

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