Structural optimizations on the 7H-pyrrolo[2,3-d]pyrimidine scaffold to develop highly selective, safe and potent JAK3 inhibitors for the treatment of Rheumatoid arthritis

Author:

He Linhong,Zhang Jie,Ling Zhen,Zeng Xianxia,Yao Hualiang,Tang Minghai,Huang Huaizheng,Xie Xin,Qin Tinsheng,Feng Xianjing,Chen Zhiquan,Deng Fengyuan,Yue Xiaoyang

Publisher

Elsevier BV

Reference25 articles.

1. Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis;Chen;Nat. Rev. Rheumatol.,2019

2. Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis;Lin;Cells.,2020

3. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors;Bahekar;Bioorg. Chem.,2020

4. Janus kinases (JAKs): The efficient therapeutic targets for autoimmune diseases and myeloproliferative disorders;Xu;Eur. J. Med. Chem.,2020

5. Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases;Clark;J. Med. Chem.,2014

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