Inhibitors designed for the active site of dihydroorotase
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry
Reference25 articles.
1. Interconversion of carbamayl-L-aspartate and L-dihydroorotate by dihydroorotase from mouse Ehrlich ascites carcinoma.
2. The effects of pH and inhibitors upon the catalytic activity of the dihydroorotase of multienzymatic protein pyr1-3 from mouse Ehrlich ascites carcinoma.
3. The overall synthesis of L-5,6-dihydroorotate by multienzymatic protein pyr1-3 from hamster cells. Kinetic studies, substrate channeling, and the effects of inhibitors.
4. Catalysis by Hamster Dihydroorotase: Zinc Binding, Site-Directed Mutagenesis, and Interaction with Inhibitors
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2. Construction of piperidine-2,4-dione-type azaheterocycles and their application in modern drug development and natural product synthesis;Organic & Biomolecular Chemistry;2020
3. Pyrimidine biosynthesis in pathogens – Structures and analysis of dihydroorotases from Yersinia pestis and Vibrio cholerae;International Journal of Biological Macromolecules;2019-09
4. Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides;ACS Combinatorial Science;2019-08-27
5. Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD;Journal of Biological Chemistry;2018-12
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