Use of a screening method to determine excipients which optimize the extent and stability of supersaturated drug solutions and application of this system to solid formulation design

Author:

Vandecruys Roger,Peeters Jef,Verreck Geert,Brewster Marcus E.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference52 articles.

1. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavaliability;Amidon;Pharm. Res.,1995

2. Appel, L.E., Babcock, W.C., Friesen, D.T., Ray, R.J., Shamblin, R.M., Smithey, D.T., 2006. Pharmaceutical dosage forms comprising a low solubility drug and polymer. International Patent Appl: WO2006024944 A2.

3. Brewster, M.E., Vandecruys, R., Peeters, J., Verreck, G., Loftsson, T., 2006. Interactions of 2-hydroxypropyl-β-cyclodextrin and sulfobutylether-β-cyclodextrin with itraconazole: stabilization of supersaturated drug solutions. J. Pharm. Sci. (submitted for publication).

4. The use of polymer-based electrospun nanofibers containing amorphous drug dispersions in the delivery of poorly water-soluble pharmaceuticals;Brewster;Pharmazie,2004

5. A novel cyclodextrin-containing glass thermoplastic systems (GTS) for formulating poorly water soluble drug candidates: preclinical and clinical results;Brewster;J. Incl. Phenom. Macro. Chem.,2003

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