A novel approach to support formulation design on twin screw wet granulation technology: Understanding the impact of overarching excipient properties on drug product quality attributes

Author:

Willecke N.,Szepes A.,Wunderlich M.,Remon J.P.,Vervaet C.,De Beer T.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference26 articles.

1. Hurter, P., AAPS Newsmagazine – August 2013 – Implementing Continuous Manufacturing to Streamline and Accelerate Drug Development.” (Online). Available: http://www.nxtbook.com/nxtbooks/aaps/newsmagazine_201308/index.php?startid=14#/14 (accessed 19-May-2016).

2. ICH Guidance for Industry, 2009. Q8(R2) Pharmaceutical Development.

3. Single-step granulation/tabletting of different grades of lactose: a comparison with high shear granulation and compression;Keleb;Eur. J. Pharm. Biopharm.,2004

4. Twin screw wet granulation: Influence of formulation parameters on granule properties and growth behavior;El Hagrasy;Powder Technol.,2013

5. Impact of microcrystalline cellulose material attributes: A case study on continuous twin screw granulation;Fonteyne;Int. J. Pharm.,2015

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