A robust, viable, and resource sparing HPLC-based logP method applied to common drugs

Author:

Coutinho Ana L.,Cristofoletti Rodrigo,Wu Fang,Shoyaib Abdullah AlORCID,Dressman Jennifer,Polli James E.ORCID

Funder

U.S. Food and Drug Administration

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference38 articles.

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2. LogP measurement of a highly hydrophobic properfume: evaluation of extrapolation of RP-HPLC results and impact of chemical moieties on accuracy: LogP> 9: Impact of Chemical Moieties on extrapolation of HPLC measures;Begnaud;Flavour Fragr. J.,2016

3. From SAR to comparative QSAR: role of hydrophobicity in the design of 4-hydroxy-5,6-dihydropyran-2-ones HIV-1 protease inhibitors;Bhhatarai;Bioorg. Med. Chem.,2005

4. Determination of hydrophobic parameters by reversed-phase liquid chromatography: theory, experimental techniques, and application in studies on quantitative structure-activity relationships;Braumann;J. Chromatogr. A,1986

5. Reverse-phase liquid chromatographic retention parameter, log kw versus liquid-liquid partition coefficient as a model of the hydrophobicity of phenylureas, s-triazines and phenoxycarbonic acid derivatives;Braumann;J. Chromatogr. Tech. Instrum. Anal. Chem.,1983

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