Biochemical characterization of desloratadine, a potent antagonist of the human histamine H1 receptor

Author:

Anthes John C,Gilchrest Helen,Richard Christian,Eckel Stephen,Hesk Dave,West Robert E,Williams Shirley M,Greenfeder Scott,Billah Motasim,Kreutner William,Egan Robert W

Publisher

Elsevier BV

Subject

Pharmacology

Reference32 articles.

1. Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists;Bakker;Eur. J. Pharmacol.,2000

2. Histamine H1-receptor activation of nuclear factor-κB: roles of Gβγ- and Gαq/11-subunits in constitutive and agonist mediated signalling;Bakker;Mol. Pharmacol.,2001

3. Characterization of the binding activity of a high affinity pseudoirreversible morpholino tachykinin NK1 receptor antagonist;Cascieri;Eur. J. Pharmacol.,1997

4. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition (IC50) of an enzymatic reaction;Cheng;Biochem. Pharmacol.,1973

5. The assessment of antagonist potency under conditions of transient response kinetics;Christopoulos;Eur. J. Pharmacol.,1999

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