Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. II. Importance of accurate toxicity measurement

Author:

Fowler Paul,Smith Robert,Smith Katie,Young Jamie,Jeffrey Laura,Kirkland David,Pfuhler Stefan,Carmichael Paul

Funder

European Cosmetic Industry Association

UK National Centre for the 3Rs

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Genetics

Reference26 articles.

1. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9;Scott;Mutat. Res.,1991

2. Directive 2003/15/EC (amending Council Directive 76/768/EEC on the approximation of the laws of the Member States relating to cosmetic products). http://ec.europa.eu/consumers/sectors/cosmetics/files/doc/200315/200315_en.pdf.

3. Evaluation of the ability of a battery of 3 in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. I. Sensitivity, specificity and relative predictivity;Kirkland;Mutat. Res.,2005

4. P. Fowler, K. Smith, J. Young, L. Jeffrey, D. Kirkland, S. Pfuhler, P. Carmichael, Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type, Mutation Research, submitted for publication.

5. Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. I. Theoretical aspects;Lorge;Mutat. Res.,2008

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