Rational Design of Alkylene-Linked Bis-Pyridiniumaldoximes as Improved Acetylcholinesterase Reactivators

Author:

Pang Yuan-Ping,Kollmeyer Thomas M.,Hong Feng,Lee Jong-Cheol,Hammond Pamela I.,Haugabouk Sharie P.,Brimijoin Stephen

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference53 articles.

1. Anticholinesterase Agents;Taylor,1996

2. A powerful reactivator of alkylphosphate-inhibited acetylcholinesterase;Wilson;Biochim. Biophys. Acta,1955

3. Reactivation of alkylphosphate inhibited acetylcholinesterase by bis quaternary derivatives of 2-pam and 4-pam;Wilson;Biochem. Pharmacol.,1958

4. Reactivation by pyridinium aldoxime methochloride (PAM) of inhibited cholinesterase activity in dogs after poisoning with pinacolyl methylphosphonofluoridate (soman);Fleisher;J. Pharmacol. Exp. Ther.,1967

5. The ph dependence of dealkylation in soman-inhibited cholinesterases and their mutants - further evidence for a push-pull mechanism;Saxena;Biochemistry,1998

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