Bio-activation of simeprevir in liver microsomes and characterization of its glutathione conjugates by liquid chromatography coupled to ultrahigh-resolution quadrupole time-of-flight mass spectrometry

Author:

Kaddah Mohamed M.Y.ORCID,Billig Susan,Oehme Ramona,Birkemeyer Claudia

Funder

DFG

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference45 articles.

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2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012, Simeprevir. [Updated 18 January 2018]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548277/. (Accessed 9 January 2019).

3. A comprehensive listing of bioactivation pathways of organic functional groups;Kalgutkar;Curr. Drug Metab.,2005

4. Determination of simeprevir: a novel, hepatitis C protease inhibitor in human plasma by high-performance liquid chromatography-tandem mass spectrometry;Vanwelkenhuysen;J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.,2014

5. A liquid chromatography-tandem mass spectrometry method for simultaneous determination of simeprevir, daclatasvir, sofosbuvir, and GS-331007 applied to a retrospective clinical pharmacological study;Ferrari;J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.,2019

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