Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells

Author:

Appelt-Menzel Antje,Cubukova Alevtina,Günther Katharina,Edenhofer Frank,Piontek Jörg,Krause Gerd,Stüber Tanja,Walles Heike,Neuhaus Winfried,Metzger Marco

Funder

LipoTrans

German Research Foundation

Stiftung zur Förderung der Erforschung von Ersatz- und Ergänzungsmethoden zur Einschränkung von Tierversuchen

Publisher

Elsevier BV

Subject

Cell Biology,Developmental Biology,Genetics,Biochemistry

Reference50 articles.

1. Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult;Al Ahmad;J. Cereb. Blood Flow Metab.,2011

2. In Vitro Assays for Assessing BBB Permeability. Blood-brain Barrier in Drug Discovery;Avdeef,2015

3. Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes;Boyer-Di Ponio;PLoS One,2014

4. Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study;Butt;J. Physiol.,1990

5. An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes and neurons derived from human induced pluripotent stem cells;Canfield;J. Neurochem,2016

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