Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
Author:
Funder
ERC
Swedish Research Council
Cancerfonden
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference35 articles.
1. The MutT proteins or “nudix” hydrolases, a family of versatile, widely distributed,“housecleaning” enzymes;Bessman;J. Biol. Chem.,1996
2. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool;Gad;Nature,2014
3. Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2;Carter;Nat. Commun.,2015
4. NUDT15 hydrolyzes 6-thio-DeoxyGTP to mediate the anticancer efficacy of 6-thioguanine;Valerie;Cancer Res.,2016
5. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia;Yang;Nat. Genet.,2014
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