Endogenous Coproporphyrin I and III are Altered in Multidrug Resistance-Associated Protein 2-Deficient (TR−) Rats
Author:
Funder
National Institutes of Health
National Institute of General Medical Sciences
Publisher
Elsevier BV
Subject
Pharmaceutical Science
Reference44 articles.
1. Coproporphyrins I and III as functional markers of OATP1B activity: in vitro and in vivo evaluation in preclinical species;Shen;J Pharmacol Exp Ther,2016
2. Coproporphyrins in plasma and urine can be appropriate clinical biomarkers to recapitulate drug-drug interactions mediated by organic anion transporting polypeptide inhibition;Lai;J Pharmacol Exp Ther,2016
3. Comparative evaluation of plasma bile acids, dehydroepiandrosterone sulfate, hexadecanedioate, and tetradecanedioate with coproporphyrins I and III as markers of OATP inhibition in healthy subjects;Shen;Drug Metab Dispos,2017
4. Further studies to support the use of coproporphyrin I and III as novel clinical biomarkers for evaluating the potential for organic anion transporting polypeptide 1B1 and OATP1B3 inhibition;Shen;Drug Metab Dispos,2018
5. Identification of endogenous biomarkers to predict the propensity of drug candidates to cause hepatic or renal transporter-mediated drug-drug interactions;Chu;J Pharm Sci,2017
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1. An Isolated Perfused Rat Liver Model: Simultaneous LC-MS Quantification of Pitavastatin, Coproporphyrin I, and Coproporphyrin III Levels in the Rat Liver and Bile;ACS Omega;2024-04-18
2. Rifampin- and Silymarin-Mediated Pharmacokinetic Interactions of Exogenous and Endogenous Substrates in a Transgenic OATP1B Mouse Model;Molecular Pharmaceutics;2024-03-26
3. The influence of OATP2B1 and atorvastatin on coproporphyrin isomers in rats;Journal of Pharmacological Sciences;2023-11
4. Influence of Slco2b1‐knockout and SLCO2B1‐humanization on coproporphyrin I and III levels in rats;British Journal of Pharmacology;2023-09-05
5. Characterization of Elimination Pathways and the Feasibility of Endogenous Metabolites as Biomarkers of Organic Anion Transporter 1/3 Inhibition in Cynomolgus Monkeys;Drug Metabolism and Disposition;2023-04-14
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