1. Pharmacodynamics;Trevor,2013
2. European Medicines Agency (2017) Guideline on strategies to identify and mitigate risks for first-in-human clinical trials with investigational medicinal products. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2017/07/WC500232186.pdf
3. United States Food and Drug Administration (2005) Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. Available at: https://www.fda.gov/downloads/drugs/guidances/ucm078932.pdf
4. An analysis of the attrition of drug candidates from four major pharmaceutical companies;Waring;Nat. Rev. Drug Discov.,2015
5. Getting pharmaceutical R&D back on target;Bunnage;Nat. Chem. Biol.,2011