Towards holistic Compound Quality Scores: Extending ligand efficiency indices with compound pharmacokinetic characteristics
Author:
Publisher
Elsevier BV
Subject
Drug Discovery,Pharmacology
Reference45 articles.
1. Managing the drug discovery/development interface;Kennedy;Drug Discov Today,1997
2. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings;Lipinski;Adv Drug Deliv Rev,1997
3. Drug-like properties and the causes of poor solubility and poor permeability;Lipinski;J Pharmacol Toxicol Methods,2000
4. Rules were made to be broken;Hartung;Nat Rev Chem,2023
5. Trends in molecular properties, bioavailability, and permeability across the Bayer compound collection;O’ Donovan;J Med Chem,2023
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