Hydroxylation of the antimalarial drug 58C80 by CYP2C9 in human liver microsomes: Comparison with mephenytoin and tolbutamide hydroxylations-Reference-Cited by-同舟云学术

Hydroxylation of the antimalarial drug 58C80 by CYP2C9 in human liver microsomes: Comparison with mephenytoin and tolbutamide hydroxylations

Published:1995-03 Issue:7 Volume:49 Page:997-1004
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Weaver Richard J.,Dickins Maurice,Burke M.Danny

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference41 articles.

1. 566C80: a potent-broad spectrum antiinfective agent with activity against malaria and opportunistic infections in AIDS patients;Hudson;Drugs Exp Clin Res,1991

2. Cytochrome P450 2C9 is responsible for hydroxylation of the naphthoquinone antimalarial drug 58C80 in human liver;Weaver;Biochem Pharmacol,1993

3. Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes;Smith;Biochem Pharmacol,1992

4. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism;Shimada;J Biol Chem,1986

5. Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily;Veronese;Biochem J,1993

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