The thienopyridine ticlopidine selectively prevents the inhibitory effects of ADP but not of adrenaline on cAMP levels raised by stimulation of the adenylate cyclase of human platelets by PGE1

Author:

Gachet Christian,Cazenave Jean-Pierre,Ohlmann Philippe,Bouloux Cyrille,Defreyn Ghyslain,Driot Francis,Maffrand Jean-Pierre

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference19 articles.

1. Ticlopidine: a promise for the prevention and treatment of thrombosis and its complications;Panak;Haemostasis,1983

2. Reviewed pharmacology of ticlopidine;Maffrand;Angiologie,1988

3. Ticlopidine, a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in platelet-dependent disease states;Saltiel;Drugs,1987

4. Broad spectrum antiplatelet activity of ticlopidine and PCR 4099 involves the suppression of the effects of released ADP;Feliste;Thromb Res,1987

5. The in vitro effect of ticlopidine on fibrinogen and factor VIII binding to human platelets;Lee;Thromb Haemost,1981

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