Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in walker cells-Reference-Cited by-同舟云学术

Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in walker cells

Published:1989-11 Issue:22 Volume:38 Page:4137-4143
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Roberts John J.,Marchbank Tania,Kotsaki-Kovatsi Vana P.,Boland Marion P.,Friedlos Frank,Knox Richard J.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference27 articles.

1. 2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of growth of the Walker carcinoma 256;Cobb;Biochem Pharmacol,1969

2. Cell hybridization study of resistance to alkalating agents;Phillips;Nature,1971

3. CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells;Roberts;Biochem Biophys Res Commun,1986

4. A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells;Knox;Biochem Pharmacol,1988

5. The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2);Knox;Biochem Pharmacol,1988

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1. uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954;Journal of Biotechnology;2010-10-01

2. Aerobic 2- and 4-nitroreduction of CB 1954 by human liver;Toxicology;2005-12

3. NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger;Molecular Pharmacology;2004-04-20

4. CB 1954: From the Walker Tumor to NQO2 and VDEPT;Current Pharmaceutical Design;2003-10-01

5. Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9;British Journal of Cancer;1997-12