Kinetic studies on 2',2'-difluorodeoxycytidine (gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase

Author:

Bouffard David Y.,Laliberté Josée,Momparler Richard L.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference30 articles.

1. Synthesis of 2-deoxy-2,2-difluoro-d-ribose and 2-deoxy-2,2-dinuoro-d-ribofuranosyl nucleosides;Hertel;J Org Chem,1988

2. Preclinical in vivo activity of 2',2'-difluorodeoxycytidine (Gemcitabine) against human head and neck cancer;Braakhuis;Cancer Res,1991

3. Pharmacokinetics of Gemcitabine (LY 188011; difluo-rodeoxycytidine) administered every two weeks in a Phase I study;Peters,1990

4. Evaluation of the antitumor activity of Gemcitabine (2',2'-difluoro-deoxycytidine);Hertel;Cancer Res,1990

5. A phase II study of Gemcitabine in non-small cell lung cancer (NSCLC) using a twice weekly schedule;Lund,1992

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