Discovery of a highly efficient TylF methyltransferase via random mutagenesis for improving tylosin production

Author:

Fan Jingyan,Yao Zhiming,Yan Chaoyue,Hao Meilin,Dai Jun,Zou Wenjin,Ni Minghui,Li Tingting,Li Lu,Li Shuo,Liu Jie,Huang Qi,Zhou Rui

Publisher

Elsevier BV

Subject

Computer Science Applications,Genetics,Biochemistry,Structural Biology,Biophysics,Biotechnology

Reference39 articles.

1. Tylosin, a new antibiotic. II. Isolation, properties, and preparation of desmycosin, a microbiologically active degradation product;Hamill;Antibiot Chemother,1961

2. Macrolide antibiotics: binding site, mechanism of action, resistance;Gaynor;Curr Top Med Chem,2003

3. 16-membered macrolide antibiotics: a review;Arsic;Int J Antimicrob Agents,2018

4. Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives;Debono;J Antibiot,1989

5. Physico-chemical properties of new acyl derivatives of tylosin produced by microbial transformation;Okamoto;J Antibiot,1980

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