1. Over 20 marketed pharmaceuticals are phenylacetic acid derivatives including diclofenac (anti-arthritic), ibufenac (anti-inflammatory), ritalin (anti-ADHD), homovanillic acid (schizophrenia), propanidid (anesthetic) guanfacine (antihypertensive), and 4-chlorophenylacetic acid (anti-neoplastic). For a selection of examples see:
2. Failli, A. A.; Kreft, A. F.; Musser, J. H. U.S. Patent 5,021,576, 1991;
3. Phenylacetic acid derivatives as hPPAR agonists
4. Synthesis of novel phenylacetic acid derivatives with halogenated benzyl subunit and evaluation as aldose reductase inhibitors