Cross-coupling reaction on N-(3,5-dibromo-2-pyridyl)piperazines: regioselective synthesis of 3,5-disubstituted pyridylpiperazines

Author:

Hikawa Hidemasa,Yokoyama Yuusaku

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference18 articles.

1. Dopamine D4 Ligands and Models of Receptor Activation:  2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Effect Responsible for Additional Efficacy Tuning

2. 4-(2-Pyridyl)piperazine-1-benzimidazoles as potent TRPV1 antagonists

3. Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors:  Structure−Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs

4. Hu, E.; Kunz, R.; Chen, N.; Nixey, T.; Hitchcock, S. WO2009025823.

5. Alexander, R.P.; Aujla, P.S.; Crepy, K.V.L.; Foley, A.M.; Franklin, R.J.; Haughan, A.F.; Horsley, H.T.; Jones, W.M.; Lallemand, B.I.L.F.; Mack, S.R.; Morgan, T.; Pasau, P.M.G.; Phillips, D.J.; Sabin, V.M.; Buckley, G.M.; Jenkins, K.; Perry, B.G. WO2008001076.

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