The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress
Author:
Funder
MEXT
strategic research foundation at private universities
Takeda Science Foundation
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Reference19 articles.
1. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer;David;Nature,2010
2. The alternative splicing repressors hnRNP A 1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism;Clower;Proc. Natl. Acad. Sci. U.S.A.,2010
3. The multifaceted regulation and functions of PKM2 in tumor progression;Li;Biochim. Biophys. Acta,2014
4. Pyruvate kinase M2: a multifarious enzyme in non-canonical localization to promote cancer progression;Amin;Biochim. Biophys. Acta Rev. Canc,2019
5. AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth;Park;Oncotarget,2016
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1. M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics;Journal of Translational Medicine;2023-12-07
2. Mechanistic Insights into Alternative Gene Splicing in Oxidative Stress and Tissue Injury;Antioxidants & Redox Signaling;2023-11-23
3. M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics;2023-09-11
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