A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17

Author:

Healy Eamonn F.ORCID,Lilic MarkoORCID

Funder

Welch Foundation

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference40 articles.

1. Cell entry mechanisms of SARS-CoV-2;Shang;Proc. Natl. Acad. Sci. U.S.A.,2020

2. The receptor that enables infection by SARS-CoV-2: biochemistry, structure,;Gross;allostery and evaluation of the potential development of ACE2 modulators ChemMedChem,2020

3. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus;Li;Nature,2003

4. TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein;Heurich;J. Virol.,2014

5. Chaperone-like properties of the prodomain of TNFalpha-converting enzyme (TACE) and the functional role of its cysteine switch;Leonard;Biochem. J.,2005

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