Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters

Author:

Jiang Weiwu,Wang Lihua,Zhang Weisheng,Coffee Richard,Fazili Inayat S.,Moorthy Bhagavatula

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference34 articles.

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2. Environmental carcinogens;Hemminki,1990

3. Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy;Guengerich;Cancer Res.,1988

4. Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6, Balb/c, and F1 mice following in utero exposure to 3-methylcholanthrene;Xu;Toxicol. Appl. Pharmacol.,2005

5. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene;Poland;Mol. Pharmacol.,1974

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