Conversion of 2′,3′-dideoxyadenosine (ddA) and 2′,3′-didehydro-2′,3′-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus-Reference-Cited by-同舟云学术

Conversion of 2′,3′-dideoxyadenosine (ddA) and 2′,3′-didehydro-2′,3′-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus

Published:1997-06-30 Issue:2-3 Volume:410 Page:324-328
ISSN:0014-5793
Container-title:FEBS Letters
language:en
Short-container-title:

Author:

Balzarini Jan,Kruining Johannes,Wedgwood Orson,Pannecouque Christophe,Aquaro Stefano,Perno Carlo-Federico,Naesens Lieve,Witvrouw Myriam,Heijtink Rudolf,De Clercq Erik,McGuigan Christopher

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1016/S0014-5793(97)00616-9/fullpdf

Reference26 articles.

1. Differential Patterns of Intracellular Metabolism of 2′,3′-Didehydro-2′,3′-dideoxythymidine and 3′-Azido-2′,3′-dideoxythymidine, Two Potent Anti-human Immunodeficiency Virus Compounds

2. Cellular metabolism of 2',3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro.

3. Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.

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