Identification of a heterozygous pathogenic variant in IRAK4 in an adult patient with pneumococcal sepsis, monoclonal gammopathy of uncertain significance, and idiopathic systemic capillary leak syndrome
Author:
Funder
National Institutes of Health
Publisher
Elsevier BV
Reference15 articles.
1. Pyogenic bacterial infections in humans with IRAK-4 deficiency;Picard;Science,2003
2. Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity;Ku;J Exp Med,2007
3. IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease;Ku;J Med Genet,2007
4. Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IκBα deficiency;Picard;Clin Microbiol Rev,2011
5. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling;Kawagoe;J Exp Med,2007
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