Vision deficits precede structural losses in a mouse model of mitochondrial dysfunction and progressive retinal degeneration

Author:

Laliberté Alex M.,MacPherson Thomas C.,Micks Taft,Yan Alex,Hill Kathleen A.

Funder

University of Western Ontario Academic Development Fund

Plunkett Foundation

Canada Institutes for Health Research

Natural Sciences and Engineering Research Council

Canada Foundation for Innovation

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Sensory Systems,Ophthalmology

Reference35 articles.

1. The variability of the harlequin mouse phenotype resembles that of human mitochondrial-complex I-deficiency syndromes;Benit;PLoS One,2008

2. Harlequin (Hq) produces progressive cerebellar cortical atrophy;Bronson;Mouse Genome,1990

3. Glutamate metabolic pathways and retinal function;Bui;J. Neurochem.,2009

4. Functional remodeling of glutamate receptors by inner retinal neurons occurs from an early stage of retinal degeneration;Chua;J. Comp. Neurol.,2009

5. Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina;Curcio;Invest. Ophthalmol. Vis. Sci.,1993

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